![]() ![]() IgG4-RD can involve one or multiple sites in the body. Renal failure, hydronephrosis, testicular pain Seizures, paralysis or hemiparesis, cranial nerve palsies, sensorineural hearing loss, pituitary hormone deficiencies Ĭonstrictive pericarditis, heart block, ruptured aortic aneurysm, aortic dissection, carotid artery dissection, intracranial aneurysm, angina, sudden cardiac death Īirway obstruction, pleural effusion Įsophageal obstruction, bowel obstruction Reported cases do include some significant symptoms or findings however: Lesions may also be detected incidentally on radiological images, but can be easily misdiagnosed as malignancies. ![]() urinary symptoms in men attributed to common prostate conditions. Symptoms are commonly attributed to other conditions and other diagnoses may have been made years before diagnosis, e.g. jaundice due to involvement of the pancreas, biliary tree or liver. Moreover, diagnosis is made due to the presence of painless swellings or mass lesions, or due to complications of masses, e.g. Laboratory levels of IGG4 greater than 135 However, it may occur as a secondary effect, for example, due to either obstruction or compression. Pain is generally not a feature of inflammation. People are often described as being generally well at the time of diagnosis, although some may give a history of weight loss. This can be in spite of considerable underlying organ destruction. Although possibly based on opinion rather than on objective assessments, symptoms, if any, are commonly described as mild in the medical literature. IgG4-related disease has been described as an indolent condition. Treatment is recommended in all symptomatic cases of IgG4-RD and also in asymptomatic IgG4-RD involving certain anatomical sites. Įarly detection is important to avoid organ damage and potentially serious complications. Inflammation and the deposition of connective tissue in affected anatomical sites can lead to organ dysfunction, organ failure, or even death if not treated. It is a relapsing-remitting disease associated with a tendency to mass forming, tissue-destructive lesions in multiple sites, with a characteristic histopathological appearance in whichever site is involved. In approximately 51–70% of people with this disease, serum IgG4 concentrations are elevated during an acute phase. IgG4-related disease ( IgG4-RD), formerly known as IgG4-related systemic disease, is a chronic inflammatory condition characterized by tissue infiltration with lymphocytes and IgG4-secreting plasma cells, various degrees of fibrosis (scarring) and a usually prompt response to oral steroids. The prostatic stroma shows a dense inflammatory infiltrate and fibrosis ( H&E, 100x) Low power view of IgG4-related prostatitis. ![]()
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